The Gomez-Lopez laboratory employs in vitro and in vivo models, as well as classic and contemporary molecular laboratory techniques in order to understand the molecular and cellular basis of obstetrical disorders, with an emphasis on preterm labor. Currently, the Gomez-Lopez laboratory has four main aims:
1. To study the mechanisms whereby damage-associated molecular patterns (DAMPs) induce sterile intra-amniotic inflammation and spontaneous preterm labor and birth.
2. To investigate the function of leukocytes in the amniotic cavity of women with intra-amniotic infection/inflammation.
3. To mechanistically elucidate the homeostatic role of innate immune cells in late gestation in order to develop strategies to prevent inflammation-induced preterm labor.
4. To mechanistically elucidate the roles of effector and regulatory T cells in spontaneous preterm labor.