Publications

View updated list of publications through Pubmed.

Selected Published Peer-Review Journals

 

  1. Gomez-Lopez N, Romero R, Garcia-Flores V, Xu Y, Leng Y, Alhousseini A, Hassan SS, Panaitescu B. Amniotic fluid neutrophils can phagocytize bacteria: A mechanism for microbial killing in the amniotic cavity. Am J Reprod Immunol. Epub 2017 Jul 13. doi: 10.1111/aji.12723.
  2. Gomez-Lopez N, Romero R, Arenas-Hernandez M, Schwenkel G, St Louis D, Hassan SS, Mial TN. In vivo activation of invariant natural killer T cells induces systemic and local alterations in T-cell subsets prior to preterm birth. Clin Exp Immunol. 2017 Aug;189(2):211-225. doi: 10.1111/cei.12968.
  3. Gomez-Lopez N, Romero R, Xu Y, Garcia-Flores V, Leng Y, Panaitescu B, Miller D, Abrahams VM, Hassan SS. Inflammasome assembly in the chorioamniotic membranes during spontaneous labor at term. Am J Reprod Immunol. 2017 May;77(5). doi: 10.1111/aji.12648.
  4. Gomez-Lopez N, Romero R, Arenas-Hernandez M, Panaitescu B, Garcia-Flores V, Mial TN, Sahi A, Hassan SS. Intra-amniotic administration of lipopolysaccharide induces spontaneous preterm labor and birth in the absence of a body temperature change. J Matern Fetal Neonatal Med. Epub 2017 Feb 23:1-8. doi: 10.1080/14767058.2017.1287894.
  5. Gomez-Lopez N, Romero R, Xu Y, Plazyo O, Unkel R, Leng Y, Than NG, Chaiworapongsa T, Panaitescu B, Dong Z, Tarca AL, Abrahams VM, Yeo L, Hassan SS. A Role for the Inflammasome in Spontaneous Preterm Labor With Acute Histologic Chorioamnionitis. Reprod Sci. Epub 2017 Jan 1. doi: 10.1177/1933719116687656.
  6. Gomez-Lopez N, Romero R, Leng Y, Garcia-Flores V, Xu Y, Miller D, Hassan SS. Neutrophil extracellular traps in acute chorioamnionitis: A mechanism of host defense. Am J Reprod Immunol. 2017 Mar;77(3). doi: 10.1111/aji.12617.
  7. Gomez-Lopez N, Romero R, Xu Y, Miller D, Unkel R, Shaman M, Jacques SM, Panaitescu B, Garcia-Flores V, Hassan SS. Neutrophil Extracellular Traps in the Amniotic Cavity of Women with Intra-Amniotic Infection: A New Mechanism of Host Defense. Reprod Sci. 2017 Aug;24(8):1139-1153. doi: 10.1177/1933719116678690.
  8. Gomez-Lopez N, Romero R, Xu Y, Plazyo O, Unkel R, Than NG, Chaemsaithong P, Chaiworapongsa T, Dong Z, Tarca AL, Abrahams VM, Yeo L, Hassan SS. A Role for the Inflammasome in Spontaneous Labor at Term with Acute Histologic Chorioamnionitis. Reprod Sci. Epub 2016 Nov 16. doi: 10.1177/1933719116675058.
  9. Plazyo O, Romero R, Unkel R, Balancio A, Mial TN, Xu Y, Dong Z, Hassan SS, Gomez-Lopez N. HMGB1 Induces an Inflammatory Response in the Chorioamniotic Membranes That Is Partially Mediated by the Inflammasome. Biol Reprod. 2016 Nov 2. pii: biolreprod.116.144139.
  10. Martinez-Varea A, Romero R, Xu Y, Miller D, Ahmed AI, Chaemsaithong P, Chaiyasit N, Yeo L, Shaman M, Lannaman K, Cher B, Hassan SS, Gomez-Lopez N. Clinical chorioamnionitis at term VII: the amniotic fluid cellular immune response. J Perinat Med. 2016 Oct 20. doi: 10.1515/jpm-2016-0225
  11. Yang Y, Arenas-Hernandez M, Gomez-Lopez N, Dai J, Parker GC, Puscheck EE, Rappolee DA. Hypoxic Stress Forces Irreversible Differentiation of a Majority of Mouse Trophoblast Stem Cells to Giant Cell Fate Despite FGF4. Biol Reprod. 2016 Sep 28. pii: biolreprod.116.138412.
  12. Gomez-Lopez N, Romero R, Arenas-Hernandez M, Ahn H, Panaitescu B, Vadillo-Ortega F, Sanchez-Torres C, Salisbury KS, Hassan SS. In vivo T-cell activation by a monoclonal αCD3ε antibody induces preterm labor and birth. Am J Reprod Immunol. 2016 Nov;76(5):386-390. doi: 10.1111/aji.12562
  13. Gomez-Lopez N, Romero R, Xu Y, Miller D, Unkel R, C MacKenzie T, Frascoli M, Hassan SS. Umbilical cord CD71+ erythroid cells are reduced in neonates born to women in spontaneous preterm labor. Am J Reprod Immunol. 2016 Oct;76(4):280-4. doi: 10.1111/aji.12556
  14. Mohammadi M, Li Y, Abebe DG, Xie Y, Kandil R, Kraus T, Gomez-Lopez N, Fujiwara T, Merkel OM. Folate receptor targeted three-layered micelles and hydrogels for gene delivery to activated macrophages. J Control Release. 2016 Aug 24. pii: S0168-3659(16)30551-X. doi: 10.1016/j.jconrel.2016.08.020.
  15. Amy-Eunice Furcron, Roberto Romero, Tara N. Mial, Amapola Balancio, Bogdan Panaitescu, Sonia S. Hassan, Aashna Sahi, Claire Nord, Nardhy Gomez-Lopez. Human Chorionic Gonadotropin Has Anti-Inflammatory Effects at the Maternal-Fetal Interface and Prevents Endotoxin-Induced Preterm Birth, but Causes Dystocia and Fetal Compromise in Mice. Biol Reprod. Epub 2016 May 4. doi:10.1095/biolreprod.116.13934
  16. Romero R, Xu Y, Plazyo O, Chaemsaithong P, Chaiworapongsa T, Unkel R, Than NG, Chiang PJ,Dong Z, Xu Z, Tarca AL, Abrahams VM, Hassan SS, Yeo L, Gomez-Lopez N. A role for the inflammasome in spontaneous labor at term. Am J Reprod Immunol 2016. ePub Mar 2016 doi:10.1111/aji.1244
  17. Yi Xu, Roberto Romero, Derek Miller, Leena Kadam, Tara N. Mial, Olesya Plazyo, Valaria Garcia-Flores, Sonia S. Hassan, Zhonghui Xu, Adi L. Tarca, Sascha Drewlo, Nardhy Gomez-Lopez. An M1-like macrophage polarization in decidual tissue during spontaneous preterm labor that is attenuated by rosiglitazone treatment. J immunol. 2016 Mar 15;196(6):2476-91. doi: 10.4049/jimmunol.1502055. Epub 2016 Feb 17
  18. Gomez-Lopez N, Romero R, Plazyo O, Panaitescu B, Furcron AE, Miller D, Roumayah T, Flom E, Hassan SS. Intra-Amniotic Administration of HMGB1 Induces Spontaneous Preterm Labor and Birth. Am J Reprod Immunol. 2016 Jan;75(1):3-7. doi: 10.1111/aji.12443.
  19. Derek St Louis, Roberto Romero, Olesya Plazyo, Marcia Arenas-Hernandez, Bogdan Panaitescu, Yi Xu, Tatjana Milovic, Zhonghui Xu, Gaurav Bhatti, Mi Qing-Sheng, Sascha Drewlo, Adi L. Tarca, Sonia S. Hassan, Nardhy Gomez-Lopez. iNKT-cell activation induces late preterm birth that is attenuated by rosiglitazone. J Immunol. 2016 Jan 6. pii: 1501962.
  20. Li Q, Gomez-Lopez N, Drewlo S, Sanchez-Rodriquez E, Dai J, Puscheck EE, Rappolee DA. Development and validation of a Rex1-RFP potency activity reporter assay that quantifies stress-forced potency loss in mouse embryonic stem cells. Stem Cells Dev. 2015 Dec 9. [Epub ahead of print
  21. Furcron AE, Romero R, Plazyo O, Unkel R, Xu Y, Hassan SS, Chaemsaithong P, Mahajan A, Gomez-Lopez N. Vaginal progesterone, but not 17α-hydroxyprogesterone caproate, has antiinflammatory effects at the murine maternal-fetal interface. Am J Obstet Gynecol. 2015 Aug 8. pii: S0002-9378(15)00861-3. doi: 10.1016/j.ajog.2015.08.010. Epub 2015 Aug 8
  22. Gomez-Lopez N, Olson DM, Robertson SA. Interleukin-6 controls uterine Th9 cells and CD8+ T regulatory cells to accelerate parturition in mice. Immunol Cell Biol. 2015 Jun 15. doi: 10.1038/icb.2015.63. [Epub ahead of print]
  23. Arenas-Hernandez M, Sanchez-Rodriguez EN, Mial TN, Robertson SA, Gomez-Lopez N. Isolation of Leukocytes from the Murine Tissues at the Maternal-Fetal Interface. J Vis Exp. 2015 May 21;(99):e52866. doi: 10.3791/52866
  24. Xu Y, Plazyo O, Romero R, Hassan SS, Gomez-Lopez N. Isolation of Leukocytes from the Human Maternal-fetal Interface. J Vis Exp. 2015 May 21;(99):e52863. doi: 10.3791/52863
  25. Arenas-Hernandez M, Romero R, St Louis D, Hassan SS, Kaye EB, Gomez-Lopez N. An imbalance between innate and adaptive immune cells at the maternal-fetal interface occurs prior to endotoxin-induced preterm birth. Cell Mol Immunol. 2015 Apr 6. doi: 10.1038/cmi.2015.22.
  26. Pappas A, Chaiworapongsa T, Romero R, Korzeniewski SJ, Cortez JC, Bhatti G, Gomez-Lopez N, Hassan SS, Shankaran S, Tarca AL. Transcriptomics of maternal and fetal membranes can discriminate between gestational-age matched preterm neonates with and without cognitive impairment diagnosed at 18-24 months. PLoS One. 2015 Mar 30;10(3):e0118573. doi: 10.1371/journal.pone.0118573. eCollection 2015.
  27. Vega-Sanchez R, Arenas-Hernandez M, Vazquez-Perez JA, Moreno-Valencia Y, Gomez-Lopez N. Evaluation of reference genes for expression studies in leukocytes from term human pregnancy. Placenta. 2015 Feb;36(2):240-5.
  28. Gomez-Lopez N, Tong WC, Arenas-Hernandez M, Tanaka S, Hajar O, Olson DM, Taggart MJ, Mitchell BF. Chemotactic Activity of Gestational Tissues Through Late Pregnancy, Term Labor, and RU486-Induced Preterm Labor in Guinea Pigs. American Journal of Reproductive Immunology. 2014 (in press, doi: 10.1111/aji.12333).
  29. Gomez-Lopez N, StLouis D, Lehr MA, Sanchez-Rodriguez EN, Arenas-Hernandez M. Immune cells in term and preterm labor. Cellular & Molecular Immunology. 2014 Nov;11(6):571-81.
  30. Castillo-Castrejon M, Meraz-Cruz N, Gomez-Lopez N, Flores-Pliego A, Beltrán-Montoya J, Viveros-Alcaráz M, Vadillo-Ortega F. American Journal of Reproductive Immunology 71(1):86-93, 2014
  31. Gomez-Lopez N, Tanaka S, Zaeem Z, Metz GA, Olson DM. Maternal circulating leukocytes display early chemotactic responsiveness during late gestation. BMC Pregnancy Childbirth;13 Suppl 1:S8, 2013
  32. Gomez-Lopez N, Vega-Sanchez R, Castillo-Castrejon M, Romero R, Cubeiro-Arreola K, Vadillo-Ortega F. Evidence for a role for the adaptive immune response in human term parturition. American Journal of Reproductive Immunology 2013; doi: 10.1111/aji.12074
  33. Gomez­Lopez N, Estrada-Gutierrez G, Colin A, Flores-Pliego A,  Flores-Escobar X, Oehninger S, Barroso G. The apoptotic pathway in fertile and subfertile men: a case-control and prospective study to examine the impact of M540 bodies on ejaculated spermatozoa. Fertility and Sterility 2013; doi:pii: S0015-0282(12)02464-8
  34. Gomez-Lopez N& Laresgoiti-Servitje E. T regulatory cells: Regulating both term and preterm labor? Immunology and Cell Biology 2012; 90:919-20.
  35. Prins JR, Gomez-Lopez N, Robertson SA. Interleukin-6 in pregnancy and gestational disorders. Journal of Reproductive Immunology 2012; 95:1-14.
  36. Laresgoiti-Servitje E & Gomez-Lopez N. The Pathophysiology of Preeclampsia Involves Altered Levels of Angiogenic Factors Promoted by Hypoxia and Autoantibody-Mediated Mechanisms. Biology of Reproduction 2012;87:36,1–7.
  37. Gomez-Lopez N, Vadillo-Ortega F, Estrada-Gutierrez G. Boyden-flow cytometry assay improves quantification and provides phenotypification of leukocyte chemotaxis, PLoS ONE 2011; 6:e28771.
  38. Gomez-Lopez N, Vadillo-Perez L, Nessim S, Olson DM, Vadillo-Ortega F. Choriodecidua and amnion exhibit selective leukocyte chemotaxis during term human labor. American Journal Obstetrics & Gynecology 2011: 204:364.e9-16.
  39. Gomez-Lopez N, Vadillo-Perez L, Hernandez-Carbajal A, Olson DM, Vadillo-Ortega F. Specific inflammatory microenvironments in the zones of the fetal membranes at term delivery. American Journal of Obstetrics & Gynecology 2011: 205:235.e15-24.
  40. Gomez-Lopez N, Laresgoiti-Servitje E, Olson DM, Estrada-Gutierrez G, Vadillo-Ortega F. The role of chemokines in term and premature rupture of the fetal membranes: a review. Biology of Reproduction 2010; 82:809-814.
  41. Laresgoiti-Servitje E, Gomez-Lopez N, Olson DM. An immunological insight into the origins of preeclampsia. Human Reproduction Update 2010;16:510-24.
  42. Gomez-Lopez N, Guilbert LJ and Olson DM. Invasion of the leukocytes into the fetal-maternal interface during pregnancy. Journal of Leukocyte Biology 2010; 88:625-33.

 

Patent

Gomez-Lopez Nand Olson DM. "Leukocyte Activation And Methods Of Use Thereof" U.S. International. Publication number WO 2012/097451 A1. Publication date 07/26/2012.