Publications

View full list of publications through Pubmed.

Selected Published Peer-Review Journals

  1. Gomez-Lopez N, Arenas-Hernandez M, Romero R, Miller D, Garcia-Flores V, Leng Y, Xu Y, Galaz J, Hassan SS, Hsu CD, Tse H, Sanchez-Torres C, Done B, Tarca AL. Regulatory T Cells Play a Role in a Subset of Idiopathic Preterm Labor/Birth and Adverse Neonatal Outcomes. Cell Rep. 2020 Jul 7;32(1):107874. doi: 10.1016/j.celrep.2020.107874. PMID: 32640239
  2. Motomura K, Romero R, Xu Y, Theis KR, Galaz J, Winters AD, Slutsky R, Garcia-Flores V, Zou C, Levenson D, Para R, Ahmad MM, Miller D, Hsu CD, Gomez-Lopez N. Intra-Amniotic Infection With Ureaplasma parvum Causes Preterm Birth and Neonatal Mortality That Are Prevented by Treatment With Clarithromycin. mBio. 2020 Jun 23;11(3):e00797-20. doi: 10.1128/mBio.00797-20. PMID: 32576673
  3. Miller D, Gershater M, Slutsky R, Romero R, Gomez-Lopez N. Maternal and Fetal T Cells in Term Pregnancy and Preterm Labor. Cell Mol Immunol. 2020 Jul;17(7):693-704. doi: 10.1038/s41423-020-0471-2. Epub 2020 May 28. PMID: 32467619
  4. Theis KR, Romero R, Winters AD, Jobe AH, Gomez-Lopez N. Lack of Evidence for Microbiota in the Placental and Fetal Tissues of Rhesus Macaques. mSphere. 2020 May 6;5(3):e00210-20. doi: 10.1128/mSphere.00210-20. PMID: 32376701
  5. Garcia-Flores V, Romero R, Furcron AE, Levenson D, Galaz J, Zou C, Hassan SS, Hsu CD, Olson D, Metz GAS, Gomez-Lopez N. Prenatal Maternal Stress Causes Preterm Birth and Affects Neonatal Adaptive Immunity in Mice. Front Immunol. 2020 Feb 26;11:254. doi: 10.3389/fimmu.2020.00254. eCollection 2020. PMID: 32174914
  6. Theis KR, Romero R, Greenberg JM, Winters AD, Garcia-Flores V, Motomura K, Ahmad MM, Galaz J, Arenas-Hernandez M, Gomez-Lopez N. No Consistent Evidence for Microbiota in Murine Placental and Fetal Tissues. mSphere. 2020 Feb 26;5(1):e00933-19. doi: 10.1128/mSphere.00933-19. PMID: 32102944
  7. Tarca AL, Romero R, Pique-Regi R, Pacora P, Done B, Kacerovsky M, Bhatti G, Jaiman S, Hassan SS, Hsu CD, Gomez-Lopez N. Amniotic Fluid Cell-Free Transcriptome: A Glimpse Into Fetal Development and Placental Cellular Dynamics During Normal Pregnancy. BMC Med Genomics. 2020 Feb 12;13(1):25. doi: 10.1186/s12920-020-0690-5. PMID: 32050959
  8. Burnham P, Gomez-Lopez N, Heyang M, Cheng AP, Lenz JS, Dadhania DM, Lee JR, Suthanthiran M, Romero R, De Vlaminck I. Separating the Signal From the Noise in Metagenomic Cell-Free DNA Sequencing. Microbiome. 2020 Feb 11;8(1):18. doi: 10.1186/s40168-020-0793-4. PMID: 32046792
  9. Gomez-Lopez N, Romero R, Schwenkel G, Garcia-Flores V, Panaitescu B, Varrey A, Ayoub F, Hassan SS, Phillippe M. Cell-Free Fetal DNA Increases Prior to Labor at Term and in a Subset of Preterm Births. Reprod Sci. 2020 Jan;27(1):218-232. doi: 10.1007/s43032-019-00023-6. Epub 2020 Jan 1. PMID: 32046392
  10. Gomez-Lopez N, Romero R, Hassan SS, Bhatti G, Berry SM, Kusanovic JP, Pacora P, Tarca AL. The Cellular Transcriptome in the Maternal Circulation During Normal Pregnancy: A Longitudinal Study. Front Immunol. 2019 Dec 17;10:2863. doi: 10.3389/fimmu.2019.02863. eCollection 2019. PMID: 31921132
  11. Galaz J, Romero R, Xu Y, Miller D, Slutsky R, Levenson D, Hsu CD, Gomez-Lopez N. Cellular Immune Responses in Amniotic Fluid of Women With Preterm Clinical Chorioamnionitis. Inflamm Res. 2020 Feb;69(2):203-216. doi: 10.1007/s00011-019-01308-x. Epub 2020 Jan 7. PMID: 31912179
  12. Pique-Regi R, Romero R, Tarca AL, Sendler ED, Xu Y, Garcia-Flores V, Leng Y, Luca F, Hassan SS, Gomez-Lopez N. Single cell transcriptional signatures of the human placenta in term and preterm parturition. Elife. 2019 Dec 12;8. pii: e52004. doi: 10.7554/eLife.52004. PubMed PMID: 31829938.
  13. Gomez-Lopez N, Motomura K, Miller D, Garcia-Flores V, Galaz J, Romero R. Inflammasomes: Their Role in Normal and Complicated Pregnancies. J Immunol. 2019  Dec 1;203(11):2757-2769. doi: 10.4049/jimmunol.1900901. Review. PubMed PMID: 31740550; PubMed Central PMCID: PMC6871659.
  14. Gomez-Lopez N, Romero R, Xu Y, Miller D, Arenas-Hernandez M, Garcia-Flores V, Panaitescu B, Galaz J, Hsu CD, Para R, Berry SM. Fetal T Cell Activation in the Amniotic Cavity during Preterm Labor: A Potential Mechanism for a Subset of Idiopathic Preterm Birth. J Immunol. 2019 Oct 1;203(7):1793-1807. doi: 10.4049/jimmunol.1900621. Epub 2019 Sep 6. PubMed PMID: 31492740; PubMed Central  PMCID: PMC6799993.
  15. Hassan SS, Gomez-Lopez N. Reducing maternal mortality: can elabela help in this fight? Lancet. 2019 Jul 6;394(10192):8-9. doi: 10.1016/S0140-6736(19)30543-4. Epub 2019 Jul 4. PubMed PMID: 31282362.
  16. Berkowitz BA, Romero R, Podolsky RH, Lins-Childers KM, Shen Y, Rosales T, Wadghiri YZ, Hoang DM, Arenas-Hernandez M, Garcia-Flores V, Schwenkel G, Panaitescu B, Gomez-Lopez N. QUEST MRI assessment of fetal brain oxidative stress in utero. Neuroimage. 2019 Oct 15;200:601-606. doi: 10.1016/j.neuroimage.2019.05.069. Epub 2019 May 31. PubMed PMID: 31158477; PubMed Central PMCID: PMC6703912.
  17. Slutsky R, Romero R, Xu Y, Galaz J, Miller D, Done B, Tarca AL, Gregor S, Hassan SS, Leng Y, Gomez-Lopez N. Exhausted and Senescent T Cells at the Maternal-Fetal Interface in Preterm and Term Labor. J Immunol Res. 2019 May 23;2019:3128010. doi: 10.1155/2019/3128010. eCollection 2019. PubMed PMID: 31263712; PubMed Central PMCID: PMC6556261.
  18. Arenas-Hernandez M, Romero R, Xu Y, Panaitescu B, Garcia-Flores V, Miller D, Ahn H, Done B, Hassan SS, Hsu CD, Tarca AL, Sanchez-Torres C, Gomez-Lopez N. Effector and Activated T Cells Induce Preterm Labor and Birth That Is Prevented by Treatment with Progesterone. J Immunol. 2019 May 1;202(9):2585-2608. doi: 10.4049/jimmunol.1801350. Epub 2019 Mar 27. PubMed PMID: 30918041; PubMed Central PMCID: PMC6570421.
  19. Leng Y, Romero R, Xu Y, Galaz J, Slutsky R, Arenas-Hernandez M, Garcia-Flores V, Motomura K, Hassan SS, Reboldi A, Gomez-Lopez N. Are B cells altered in the decidua of women with preterm or term labor? Am J Reprod Immunol. 2019 May;81(5):e13102. doi: 10.1111/aji.13102. Epub 2019 Mar 29. PubMed PMID: 30768818; PubMed Central PMCID: PMC6556388.
  20. Gomez-Lopez N, Romero R, Garcia-Flores V, Leng Y, Miller D, Hassan SS, Hsu CD, Panaitescu B. Inhibition of the NLRP3 inflammasome can prevent sterile intra-amniotic inflammation, preterm labor/birth, and adverse neonatal outcomes†. Biol Reprod. 2019 May 1;100(5):1306-1318. doi: 10.1093/biolre/ioy264. PubMed PMID: 30596885; PubMed Central PMCID: PMC6497524.
  21. Faro J, Romero R, Schwenkel G, Garcia-Flores V, Arenas-Hernandez M, Leng Y, Xu Y, Miller D, Hassan SS, Gomez-Lopez N. Intra-amniotic inflammation induces preterm birth by activating the NLRP3 inflammasome†. Biol Reprod. 2019 May 1;100(5):1290-1305. doi: 10.1093/biolre/ioy261. PubMed PMID: 30590393; PubMed Central PMCID: PMC6698670.
  22. Miller D, Motomura K, Garcia-Flores V, Romero R, Gomez-Lopez N. Innate Lymphoid Cells in the Maternal and Fetal Compartments. Front Immunol. 2018 Oct 26;9:2396. doi: 10.3389/fimmu.2018.02396. eCollection 2018. Review. PubMed PMID: 30416502; PubMed Central PMCID: PMC6212529.
  23. Garcia-Flores V, Romero R, Miller D, Xu Y, Done B, Veerapaneni C, Leng Y, Arenas-Hernandez M, Khan N, Panaitescu B, Hassan SS, Alvarez-Salas LM, Gomez-Lopez N. Inflammation-Induced Adverse Pregnancy and Neonatal Outcomes Can Be Improved by the Immunomodulatory Peptide Exendin-4. Front Immunol. 2018 Jun 18;9:1291. doi: 10.3389/fimmu.2018.01291. eCollection 2018. PubMed PMID: 29967606; PubMed Central PMCID: PMC6015905.
  24. Frascoli M, Coniglio L, Witt R, Jeanty C, Fleck-Derderian S, Myers DE, Lee TH, Keating S, Busch MP, Norris PJ, Tang Q, Cruz G, Barcellos LF, Gomez-Lopez N,  Romero R, MacKenzie TC. Alloreactive fetal T cells promote uterine contractility in preterm labor via IFN-γ and TNF-α. Sci Transl Med. 2018 Apr 25;10(438). pii: eaan2263. doi: 10.1126/scitranslmed.aan2263. PubMed PMID: 29695455; PubMed Central PMCID: PMC6449052.
  25. Gomez-Lopez N, Romero R, Xu Y, Miller D, Leng Y, Panaitescu B, Silva P, Faro J, Alhousseini A, Gill N, Hassan SS, Hsu CD. The immunophenotype of amniotic fluid leukocytes in normal and complicated pregnancies. Am J Reprod Immunol. 2018 Apr;79(4):e12827. doi: 10.1111/aji.12827. Epub 2018 Mar 3. PubMed PMID: 29500850; PubMed Central PMCID: PMC5951617.
  26. Xu Y, Romero R, Miller D, Silva P, Panaitescu B, Theis KR, Arif A, Hassan SS, Gomez-Lopez N. Innate lymphoid cells at the human maternal-fetal interface in spontaneous preterm labor. Am J Reprod Immunol. 2018 Jun;79(6):e12820. doi: 10.1111/aji.12820. Epub 2018 Feb 19. PubMed PMID: 29457302; PubMed Central PMCID: PMC5948134.
  27. Miller D, Romero R, Unkel R, Xu Y, Vadillo-Ortega F, Hassan SS, Gomez-Lopez N. CD71+ erythroid cells from neonates born to women with preterm labor regulate cytokine and cellular responses. J Leukoc Biol. 2018 Apr;103(4):761-775. doi: 10.1002/JLB.5A0717-291RRR. Epub 2018 Feb 1. PubMed PMID: 29389020; PubMed Central PMCID: PMC5987205.
  28. Gomez-Lopez N, Romero R, Xu Y, Leng Y, Garcia-Flores V, Miller D, Jacques SM, Hassan SS, Faro J, Alsamsam A, Alhousseini A, Gomez-Roberts H, Panaitescu B, Yeo  L, Maymon E. Are amniotic fluid neutrophils in women with intraamniotic infection and/or inflammation of fetal or maternal origin? Am J Obstet Gynecol. 2017 Dec;217(6):693.e1-693.e16. doi: 10.1016/j.ajog.2017.09.013. Epub 2017 Sep 28. PubMed PMID: 28964823; PubMed Central PMCID: PMC5878926.
  29. Gomez-Lopez N, Romero R, Plazyo O, Schwenkel G, Garcia-Flores V, Unkel R, Xu Y, Leng Y, Hassan SS, Panaitescu B, Cha J, Dey SK. Preterm labor in the absence of acute histologic chorioamnionitis is characterized by cellular senescence of the chorioamniotic membranes. Am J Obstet Gynecol. 2017 Nov;217(5):592.e1-592.e17. doi: 10.1016/j.ajog.2017.08.008. Epub 2017 Aug 25. PubMed PMID: 28847437; PubMed Central PMCID: PMC5800423.
  30. Gomez-Lopez N, Romero R, Arenas-Hernandez M, Schwenkel G, St Louis D, Hassan SS, Mial TN. In vivo activation of invariant natural killer T cells induces systemic and local alterations in T-cell subsets prior to preterm birth. Clin Exp Immunol. 2017 Aug;189(2):211-225. doi: 10.1111/cei.12968. Epub 2017 May 10. PubMed PMID: 28369855; PubMed Central PMCID: PMC5508324.
  31. Gomez-Lopez N, Romero R, Xu Y, Garcia-Flores V, Leng Y, Panaitescu B, Miller D, Abrahams VM, Hassan SS. Inflammasome assembly in the chorioamniotic membranes during spontaneous labor at term. Am J Reprod Immunol. 2017 May;77(5). doi: 10.1111/aji.12648. Epub 2017 Feb 24. PubMed PMID: 28233423; PubMed Central PMCID: PMC5429868.
  32. Gomez-Lopez N, Romero R, Leng Y, Garcia-Flores V, Xu Y, Miller D, Hassan SS. Neutrophil extracellular traps in acute chorioamnionitis: A mechanism of host defense. Am J Reprod Immunol. 2017 Mar;77(3). doi: 10.1111/aji.12617. Epub 2017 Jan 3. PubMed PMID: 28045214; PubMed Central PMCID: PMC5370569.
  33. Gomez-Lopez N, Romero R, Xu Y, Miller D, Unkel R, Shaman M, Jacques SM, Panaitescu B, Garcia-Flores V, Hassan SS. Neutrophil Extracellular Traps in the Amniotic Cavity of Women with Intra-Amniotic Infection: A New Mechanism of Host Defense. Reprod Sci. 2017 Aug;24(8):1139-1153. doi: 10.1177/1933719116678690. Epub 2016 Nov 24. PubMed PMID: 27884950; PubMed Central PMCID: PMC6343453.
  34. Plazyo O, Romero R, Unkel R, Balancio A, Mial TN, Xu Y, Dong Z, Hassan SS, Gomez-Lopez N. HMGB1 Induces an Inflammatory Response in the Chorioamniotic Membranes That Is Partially Mediated by the Inflammasome. Biol Reprod. 2016 Dec;95(6):130. doi: 10.1095/biolreprod.116.144139. Epub 2016 Nov 2. PubMed PMID: 27806943; PubMed Central PMCID: PMC5315428.
  35. Furcron AE, Romero R, Mial TN, Balancio A, Panaitescu B, Hassan SS, Sahi A, Nord C, Gomez-Lopez N. Human Chorionic Gonadotropin Has Anti-Inflammatory Effects at the Maternal-Fetal Interface and Prevents Endotoxin-Induced Preterm Birth, but Causes Dystocia and Fetal Compromise in Mice. Biol Reprod. 2016 Jun;94(6):136. doi: 10.1095/biolreprod.116.139345. Epub 2016 May 4. PubMed PMID: 27146032; PubMed Central PMCID: PMC4946806.
  36. Xu Y, Romero R, Miller D, Kadam L, Mial TN, Plazyo O, Garcia-Flores V, Hassan SS, Xu Z, Tarca AL, Drewlo S, Gomez-Lopez N. An M1-like Macrophage Polarization in Decidual Tissue during Spontaneous Preterm Labor That Is Attenuated by Rosiglitazone Treatment. J Immunol. 2016 Mar 15;196(6):2476-2491. doi: 10.4049/jimmunol.1502055. Epub 2016 Feb 17. PubMed PMID: 26889045; PubMed Central PMCID: PMC4779725.
  37. Gomez-Lopez N, Romero R, Plazyo O, Panaitescu B, Furcron AE, Miller D, Roumayah T, Flom E, Hassan SS. Intra-Amniotic Administration of HMGB1 Induces Spontaneous Preterm Labor and Birth. Am J Reprod Immunol. 2016 Jan;75(1):3-7. doi: 10.1111/aji.12443. PubMed PMID: 26781934; PubMed Central PMCID: PMC5029853.
  38. St Louis D, Romero R, Plazyo O, Arenas-Hernandez M, Panaitescu B, Xu Y, Milovic T, Xu Z, Bhatti G, Mi QS, Drewlo S, Tarca AL, Hassan SS, Gomez-Lopez N. Invariant NKT Cell Activation Induces Late Preterm Birth That Is Attenuated by Rosiglitazone. J Immunol. 2016 Feb 1;196(3):1044-59. doi: 10.4049/jimmunol.1501962. Epub 2016 Jan 6. PubMed PMID: 26740111; PubMed Central PMCID: PMC4724534.
  39. Furcron AE, Romero R, Plazyo O, Unkel R, Xu Y, Hassan SS, Chaemsaithong P, Mahajan A, Gomez-Lopez N. Vaginal progesterone, but not 17α-hydroxyprogesterone caproate, has antiinflammatory effects at the murine maternal-fetal interface. Am J Obstet Gynecol. 2015 Dec;213(6):846.e1-846.e19. doi: 10.1016/j.ajog.2015.08.010. Epub 2015 Aug 8. PubMed PMID: 26264823; PubMed Central PMCID: PMC4729364.
  40. Gomez-Lopez N, Olson DM, Robertson SA. Interleukin-6 controls uterine Th9 cells and CD8(+) T regulatory cells to accelerate parturition in mice. Immunol Cell Biol. 2016 Jan;94(1):79-89. doi: 10.1038/icb.2015.63. Epub 2015 Jun 15. PubMed PMID: 26073576.
  41. Arenas-Hernandez M, Romero R, St Louis D, Hassan SS, Kaye EB, Gomez-Lopez N. An imbalance between innate and adaptive immune cells at the maternal-fetal interface occurs prior to endotoxin-induced preterm birth. Cell Mol Immunol. 2016 Jul;13(4):462-73. doi: 10.1038/cmi.2015.22. Epub 2015 Apr 6. PubMed PMID: 25849119; PubMed Central PMCID: PMC4947814.
  42. Xu Y, Plazyo O, Romero R, Hassan SS, Gomez-Lopez N. Isolation of Leukocytes from the Human Maternal-fetal Interface. J Vis Exp. 2015 May 21;(99):e52863. doi: 10.3791/52863. PubMed PMID: 26067211; PubMed Central PMCID: PMC4467471.
  43. Arenas-Hernandez M, Sanchez-Rodriguez EN, Mial TN, Robertson SA, Gomez-Lopez N. Isolation of Leukocytes from the Murine Tissues at the Maternal-Fetal Interface. J Vis Exp. 2015 May 21;(99):e52866. doi: 10.3791/52866. PubMed PMID: 26067389; PubMed Central PMCID: PMC4542974.
  44. Gomez-Lopez N, StLouis D, Lehr MA, Sanchez-Rodriguez EN, Arenas-Hernandez M. Immune cells in term and preterm labor. Cell Mol Immunol. 2014 Nov;11(6):571-81. doi: 10.1038/cmi.2014.46. Epub 2014 Jun 23. Review. PubMed PMID: 24954221; PubMed Central PMCID: PMC4220837.
  45. Gomez-Lopez N, Vega-Sanchez R, Castillo-Castrejon M, Romero R, Cubeiro-Arreola K, Vadillo-Ortega F. Evidence for a role for the adaptive immune response in human term parturition. Am J Reprod Immunol. 2013 Mar;69(3):212-30. doi: 10.1111/aji.12074. Epub 2013 Jan 24. PubMed PMID: 23347265; PubMed Central PMCID: PMC3600361.
  46. Gomez-Lopez N, Laresgoiti-Servitje E. T regulatory cells: regulating both term and preterm labor? Immunol Cell Biol. 2012 Nov;90(10):919-20. doi: 10.1038/icb.2012.48. Epub 2012 Oct 2. PubMed PMID: 23032368.
  47. Gomez-Lopez N, Vadillo-Perez L, Nessim S, Olson DM, Vadillo-Ortega F. Choriodecidua and amnion exhibit selective leukocyte chemotaxis during term human labor. Am J Obstet Gynecol. 2011 Apr;204(4):364.e9-16. doi: 10.1016/j.ajog.2010.11.010. Epub 2011 Feb 5. PubMed PMID: 21296334.
  48. Gomez-Lopez N, Guilbert LJ, Olson DM. Invasion of the leukocytes into the fetal-maternal interface during pregnancy. J Leukoc Biol. 2010 Oct;88(4):625-33. doi: 10.1189/jlb.1209796. Epub 2010 Jun 2. Review. PubMed PMID: 20519637.
  49. Laresgoiti-Servitje E, Gómez-López N, Olson DM. An immunological insight into the origins of pre-eclampsia. Hum Reprod Update. 2010 Sep-Oct;16(5):510-24. doi: 10.1093/humupd/dmq007. Epub 2010 Apr 12. Review. PubMed PMID: 20388637.
  50. Gomez-Lopez N, Laresgoiti-Servitje E, Olson DM, Estrada-Gutiérrez G, Vadillo-Ortega F. The role of chemokines in term and premature rupture of the fetal membranes: a review. Biol Reprod. 2010 May;82(5):809-14. doi: 10.1095/biolreprod.109.080432. Epub 2010 Jan 20. Review. PubMed PMID: 20089887.
  51. Gomez-Lopez N, Estrada-Gutierrez G, Jimenez-Zamudio L, Vega-Sanchez R, Vadillo-Ortega F. Fetal membranes exhibit selective leukocyte chemotaxic activity during human labor. J Reprod Immunol. 2009 Jun;80(1-2):122-31. doi: 10.1016/j.jri.2009.01.002. Epub 2009 Apr 29. PubMed PMID: 19406481

 

Patent

Gomez-Lopez Nand Olson DM. "Leukocyte Activation And Methods Of Use Thereof" U.S. International. Publication number WO 2012/097451 A1. Publication date 07/26/2012.